![]() ![]() Published by Oxford University Press on behalf of the Society for Molecular Biology and Evolution. Arvind Murugan works on how organisms enhance information uptake from the environment by using inference from past experience and has applied such ideas to self-assembly dynamics, olfaction, circadian clocks and stress-response pathways. By providing a generic mechanistic origin for experimentally observed global epistasis, our work suggests that slow collective physical modes can make biological systems evolvable.Įpistasis evolvability genotype–phenotype map global epistasis. ![]() This constraint, in turn, reduces the ruggedness of the sequence-to-function map. Such epistasis can be summarized as resulting from a global nonlinearity applied to an underlying linear trait, that is, as global epistasis. Consequently, epistatic coefficients for different combinations of mutations are no longer independent, even if individually strong. In each, we find that if the long-time physical dynamics is dominated by a slow, collective mode, then the dimensionality of mutational effects is reduced. We analyze models and experimental data on proteins and regulatory networks. Here, we demonstrate that the physical dynamics of a biological system can generically constrain epistasis. The underlying mechanistic determinants of such epistasis are unclear. ![]() Living systems evolve one mutation at a time, but a single mutation can alter the effect of subsequent mutations. ![]()
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